| Ordering Code | 340T |
|---|---|
| Test Name | Vancomycin (Trough) |
| Alias | Trough Vancocin |
| Preferred Specimen | Plasma |
| Preferred Container | EDTA, K2 (Lavender) |
| Other Specimen/Container | Plasma in Lithium Heparin (Green), Serum in Plain (Red) |
| Optimum Volume | 0.5 mL |
| Collection Instructions | Collect specimen just prior to the next dose. |
| Handling Instructions | QMC Draws: Transport EDTA tube to the QMC Lab within 2 hours of collection Other Draws: Plasma in EDTA or Lithium Heparin/Serum in Plain (Red): Send aliquot. |
| Transport Requirements | Oahu: Refrigerated Airline: Refrigerated |
| Specimen Stability | Ambient: 48 Hours (aliquot) Refrigerated: 14 Days (aliquot) Frozen: 12 Months (aliquot) Frozen samples should be thawed only once. |
| Rejection Criteria | Grossly hemolyzed, Specimen older than stability limits, Uncentrifuged unaliquoted Plasma in EDTA or Lithium Heparin/ Serum in Plain (Red) specimens >2 hours old |
| Avail. Stat | YES |
| Analytic Time | 1 Day |
| Methodology | Kinetic interaction of microparticles (KIMS) |
Reference range(s)
The reference ranges listed below are valid on this date of November 21, 2024.
| Component | Age | Male Norm | Male Critical Low | Male Critical High | Female Norm | Female Critical High | Female Critical Low | Units | Add'l info |
|---|---|---|---|---|---|---|---|---|---|
| Vancomycin (Trough) | ALL | 10-20 | 10-20 | ug/mL | Therapeutic Range: ... Note1 |
Note1:
Therapeutic Range:Trough: = 10 - 20 ug/mL
Minimum serum trough concentration should be above 10 ug/mL to avoid development of resistance. A trough concentration of 15 - 20 ug/mL is recommended for complicated infections caused by S. Aureus in which the MIC to Vancomycin is 1
(Am J Health-Syst Pharm 2017; 74 (14): 1067-1075) .