Test directory: Teriflunomide (TDM), Serum

Ordering Code5297
Test NameTeriflunomide (TDM), Serum
Preferred SpecimenSerum
Preferred ContainerPlain (Red)
Other Specimen/ContainerPlasma in EDTA, K2 (Lavender)
Optimum Volume1 mL
Handling InstructionsPromptly centrifuge and separate Serum or Plasma into a plastic screw capped vial.
Transport RequirementsOahu: Refrigerated
Airline: Refrigerated
Specimen StabilityAmbient: 30 Days
Refrigerated: 30 Days
Frozen: 10 Months
Rejection CriteriaGel barrier tube, Frozen (-20 degree C)
Avail. StatNO
Analytic TimeUp to 7 Days
MethodologyHigh Performance Liquied Chromotography/Tandem Mass
Spectrometry (LC-MS/MS)
Reference Lab National Medical Services, Inc.

Reference range(s)

ComponentAgeMale NormMale Critical LowMale Critical HighFemale NormFemale Critical HighFemale Critical LowUnitsAdd'l info
Teriflunomide (TDM)ALLng/mL

Teriflunomide...

Teriflunomide is indicated for the treatment of patients with relapsing forms of multiple sclerosis
It takes approximately 3 months to reach steady-state concentrations

Recommended doses of teriflunomide and leflunomide result in a similar range of teriflunomide plasma concentrations. Based on this, the expected therapeutic range is between 18000 ng/mL and 63000 ng/mL

Following completion of an elimination regimen, plasma concentrations should be determined twice at least 14 days apart to verify that concentrations are less than 20 ng/mL. THIS TEST IS NOT MEANT TO MONITOR THE
ELIMINATION OF TERIFLUNOMIDE IN WOMEN OF CHILDBEARING
POTENTIAL WHO DISCONTINUE TERIFLUNOMIDE. The drug carries a black box warning for hepatotoxicity and teratogenicity

See report.