Test directory: Lacosamide

Ordering Code5609
Test NameLacosamide
Preferred SpecimenSerum
Preferred ContainerPlain (Red)
Other Specimen/ContainerPlasma in EDTA, K2 (Lavender)
Optimum Volume1 mL
Handling InstructionsPromptly centrifuge and separate Serum or Plasma into a plastic capped vial.
Transport RequirementsOahu: Ambient
Airline: Refrigerated
Specimen StabilityAmbient: 30 Days
Refrigerated: 30 Days
Frozen: 10 Months
Rejection CriteriaGel barrier tube
Avail. StatNO
Analytic TimeUp to 1 Day
Reference Lab National Medical Services, Inc.

Reference range(s)

ComponentAgeMale NormMale Critical LowMale Critical HighFemale NormFemale Critical HighFemale Critical LowUnitsAdd'l info
Lacosamide, Serum/PlasmaALL

Peak plasma...

Peak plasma concentrations are reached 1 to 2 hours after a single oral or intravenous dose with a half-life of 13 hours

Following a single 200 mg dose administered as a 30-minute infusion, a 60-minute infusion, or orally as a tablet to 24 male subjects, mean maximum plasma lacosamide concentrations were 5.95 +/- 1.49, 5.38 +/- 1.10 and 5.15 +/- 1.4 mcg/mL, respectively

Mean plasma concentrations following maintenance doses: 200 mg/day: 4.99 +/- 2.51 mcg/mL; 400 mg/day: 9.35 +/- 4.22 mcg/mL; 600 mg/day: 12.46 +/- 5.60 mcg/mL

NMS Labs derived data: 5th - 95th Percentile Data: 1.8 - 13.0 mcg/mL
Mean: 5.3 mcg/mL (N = 14900)
Analysis by High Performance Liquid
Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
See report.