Test directory: Lacosamide

Ordering Code 5609
Test Name Lacosamide
Alias Vimpat
Preferred Specimen Serum
Preferred Container Plain (Red)
Other Specimen/Container Plasma in EDTA, K2 (Lavender)
Optimum Volume 1 mL
Handling Instructions Promptly centrifuge and separate Serum or Plasma into a plastic capped vial.
Transport Requirements Oahu: Ambient
Airline: Refrigerated
Specimen Stability Ambient: 30 Days
Refrigerated: 30 Days
Frozen: 10 Months
Rejection Criteria Gel barrier tube
Avail. Stat NO
Analytic Time Up to 1 Day
Methodology LC-MS/MS
Reference Lab  National Medical Services, Inc.

Reference range(s)

The reference ranges listed below are valid on this date of June 29, 2025.
Component Age Male Norm Male Critical Low Male Critical High Female Norm Female Critical High Female Critical Low Units Add'l info
Lacosamide, Serum/Plasma ALL

Peak plasma...
Peak plasma concentrations are reached 1 to 2 hours after a single oral or intravenous dose with a half-life of 13 hours

Following a single 200 mg dose administered as a 30-minute infusion, a 60-minute infusion, or orally as a tablet to 24 male subjects, mean maximum plasma lacosamide concentrations were 5.95 +/- 1.49, 5.38 +/- 1.10 and 5.15 +/- 1.4 mcg/mL, respectively

Mean plasma concentrations following maintenance doses: 200 mg/day: 4.99 +/- 2.51 mcg/mL; 400 mg/day: 9.35 +/- 4.22 mcg/mL; 600 mg/day: 12.46 +/- 5.60 mcg/mL

NMS Labs derived data: 5th - 95th Percentile Data: 1.8 - 13.0 mcg/mL
Mean: 5.3 mcg/mL (N = 14900)
Analysis by High Performance Liquid
Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
See report.
Note1

Note1:


Peak plasma concentrations are reached 1 to 2 hours after a single oral or intravenous dose with a half-life of 13 hours

Following a single 200 mg dose administered as a 30-minute infusion, a 60-minute infusion, or orally as a tablet to 24 male subjects, mean maximum plasma lacosamide concentrations were 5.95 +/- 1.49, 5.38 +/- 1.10 and 5.15 +/- 1.4 mcg/mL, respectively

Mean plasma concentrations following maintenance doses: 200 mg/day: 4.99 +/- 2.51 mcg/mL; 400 mg/day: 9.35 +/- 4.22 mcg/mL; 600 mg/day: 12.46 +/- 5.60 mcg/mL

NMS Labs derived data: 5th - 95th Percentile Data: 1.8 - 13.0 mcg/mL
Mean: 5.3 mcg/mL (N = 14900)
Analysis by High Performance Liquid
Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
See report..