Reference range(s)
The reference ranges listed below are valid on this date of December 3, 2024.
| Component | Age | Male Norm | Male Critical Low | Male Critical High | Female Norm | Female Critical High | Female Critical Low | Units | Add'l info |
|---|---|---|---|---|---|---|---|---|---|
| Lacosamide, Serum/Plasma | ALL | Peak plasma... Note1 |
Note1:
Peak plasma concentrations are reached 1 to 2 hours after a single oral or intravenous dose with a half-life of 13 hours
Following a single 200 mg dose administered as a 30-minute infusion, a 60-minute infusion, or orally as a tablet to 24 male subjects, mean maximum plasma lacosamide concentrations were 5.95 +/- 1.49, 5.38 +/- 1.10 and 5.15 +/- 1.4 mcg/mL, respectively
Mean plasma concentrations following maintenance doses: 200 mg/day: 4.99 +/- 2.51 mcg/mL; 400 mg/day: 9.35 +/- 4.22 mcg/mL; 600 mg/day: 12.46 +/- 5.60 mcg/mL
NMS Labs derived data: 5th - 95th Percentile Data: 1.8 - 13.0 mcg/mL
Mean: 5.3 mcg/mL (N = 14900)
Analysis by High Performance Liquid
Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
See report..